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Most frequently asked questions and answers.Fucoidan Facts

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The health benefits of the Agaricus Blazei mushroom. Agaricus is often praised as the “Mushroom of God” or “The King of Mushrooms” due to its health-supporting benefits. Everywhere people are raving about this amazing mushroom that supports the immune system, cellular health, and blood sugar levels. Over 500,000 people have turned to the Agaricus blazei mushroom to support a healthy immune system in order to fight off minor and major health challenges.
IMPORTANT UPDATES FROM: 4/5/22
THE NATIONAL CANCER INSTITUTE
We are excited to forward this information to everyone regarding 'Agaricus blazei Murill Extract' that has been defined by the National Cancer Institute as a dietary supplement with potential chemopreventative, antineoplastic and immunopotentiating activities. The complete definition of this dietary supplement can be found below.

One of the products sold at Superfood Science, Agaricus Bio Super Liquid, contains Agaricus blazei Murill extract. 
We hope this information is find useful.
Agaricus blazei Murill Extract is defined as:

A dietary supplement containing an extract of the Basidiomycete fungus Agaricus blazei Murill with potential chemopreventive, antineoplastic and immunopotentiating activities. Agaricus blazei Murill extract contains high levels of phytochemicals, especially beta-D-glucans. Beta-D-glucans may promote dendritic cell (DC) maturation; increase interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and immunoglobulin levels; and may enhance natural killer (NK) cell activity, potentially boosting anti-tumor host immune responses.

To review the National Cancer Institute definitions of the highlighed terms, please review the attached link highlighted in YELLOW below:

Antineoplastic: Blocking the formation of neoplasms (a new and abnormal growth of tissue in some part of the body). 

Chemoprevention: The use of drugs, vitamins, or other agents to try to reduce the risk of, or delay the development or recurrence of, harmful cell mutations.

For more information, please click here.

NEW Sasa Bamboo Leaf Extract

“The immune system is the defense against infectious organisms and other invaders.
Through a series of steps called the immune response, the immune system attacks organisms and substances that invade our systems.”

Cognitive Rescue Brain Health Capsules

Super Food Organic Turkey and Chicken Dog Treats​

NEWLY Published Fucoidan Studies


Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication—Potential Implication of Sirtuins
Published May 20, 2020
Jasmina Dimitrova-Shumkovska, Ljupcho Krstanoski, and Leo Veenman

Abstract:
Increased interest in natural antioxidants has brought to light the fucoidans (sulfated polysaccharides present in brown marine algae) as highly valued nutrients as well as effective and safe therapeutics against several diseases. Based on their satisfactory in vitro antioxidant potency, researchers have identified this molecule as an efficient remedy for neuropathological as well as metabolic disorders. Some of this therapeutic activity is accomplished by upregulation of cytoprotective molecular pathways capable of restoring the enzymatic antioxidant activity and normal mitochondrial functions. Sirtuin-3 has been discovered as a key player for achieving the neuroprotective role of fucoidan by managing these pathways, whose ultimate goal is retrieving the entirety of the antioxidant response and preventing apoptosis of neurons, thereby averting neurodegeneration and brain injuries. Another pathway whereby fucoidan exerts neuroprotective capabilities is by interactions with P-selectin on endothelial cells, thereby preventing macrophages from entering the brain proper. Furthermore, beneficial influences of fucoidan have been established in hepatocytes after xenobiotic induced liver injury by decreasing transaminase leakage and autophagy as well as obtaining optimal levels of intracellular fiber, which ultimately prevents fibrosis. The hepatoprotective role of this marine polysaccharide also includes a sirtuin, namely sirtuin-1 overexpression, which alleviates obesity and insulin resistance through suppression of hyperglycemia, reducing inflammation and stimulation of enzymatic antioxidant response. While fucoidan is very effective in animal models for brain injury and neuronal degeneration, in general, it is accepted that fucoidan shows somewhat limited potency in liver. Thus far, it has been used in large doses for treatment of acute liver injuries. Thus, it appears that further optimization of fucoidan derivatives may establish enhanced versatility for treatments of various disorders, in addition to brain injury and disease.

Potential benefits of dietary seaweeds as protection against COVID19

Published December 22, 2020
By Kenichi Tamama


ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic in Japan is not as disastrous as it is in other Western countries, possibly because of certain lifestyle factors. One such factor might be the seaweed-rich diet commonly consumed in Japan. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which binds to angiotensin-converting enzyme 2 (ACE2) on the cell surface and downregulates ACE2, likely elevating the ratio of angiotensin-converting enzyme (ACE) to ACE2. The overreaction of the immune system, combined with the cytokine storm and ACE dominance, is purported to cause the condition of COVID-19 patients to deteriorate rapidly. Dietary seaweeds contain numerous components, including ACE inhibitory peptides, soluble dietary fibers (eg, fucoidan, porphyran), omega-3 fatty acids, fucoxanthin, fucosterol, vitamins D3 and B12, and phlorotannins. These components exert antioxidant, anti-inflammatory, and antiviral effects directly as well as indirectly through prebiotic effects. It is possible that ACE inhibitory components could minimize the ACE dominance caused by SARS-CoV-2 infection. Thus, dietary seaweeds might confer protection against COVID-19 through multiple mechanisms. Overconsumption of seaweeds should be avoided, however, as seaweeds contain high levels of iodine.

The anti-cancer effects of fucoidan:
a review of both in vivo and in vitro investigations
Published May 7, 2020
Yuan Lin, Xingsi Qi, Hengjian Liu, Kuijin Xue, Shan Xu & Zibin Tian 


Abstract
Fucoidan is a kind of the polysaccharide, which comes from brown algae and comprises of sulfated fucose residues. It has shown a large range of biological activities in basic researches, including many elements like anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic, and anti-Helicobacter pylori, etc. Cancer is a multifactorial disease of multiple causes. Most of the current chemotherapy drugs for cancer therapy are projected to eliminate the ordinary deregulation mechanisms in cancer cells. Plenty of wholesome tissues, however, are also influenced by these chemical cytotoxic effects. Existing researches have demonstrated that fucoidan can directly exert the anti-cancer actions through cell cycle arrest, induction of apoptosis, etc., and can also indirectly kill cancer cells by activating natural killer cells, macrophages, etc. Fucoidan is used as a new anti-tumor drug or as an adjuvant in combination with an anti-tumor drug because of its high biological activity, wide source, low resistance to drug resistance and low side effects. This paper reviews the mechanism by which fucoidan can eliminate tumor cells, delay tumor growth and synergize with anticancer chemotherapy drugs in vitro, in vivo and in clinical trials.

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study
Published September 13, 2019
Utako Murai, Kazumasa Yamagishi, Mizuki Sata, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Junko Ishihara, Manami Inoue, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane, JPHC Study Group
 
Abstract

Background
The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established.
Objectives
We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population.
Methods
We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40–69 y). Seaweed intake was determined by FFQ at baseline (1990–1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95% CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors.

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The United States National Library of Medicine

May 1, 2019

Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy

Anti-cancer effect of fucoidan

Cancer imposes a huge burden on society and has been identified as the leading cause of death in both more and less economically developed countries [13]. In 2012, the International Agency for Research on Cancer (IARC) estimated that there were approximately 14 million new cancer cases and 8.2 million cancer deaths worldwide. By 2030, considering the growth and aging of the world population, 22 million new cancer cases and 13 million cancer deaths are expected annually. Due to changes in lifestyle such as smoking habits, poor diet, physical inactivity, and fewer childbirths, the future cancer burden will probably be even worse in economically developing countries.
Human cancer is characterized by aberrant growth and metastatic abnormal cells; uncontrolled spread (metastasis) results in death of the host. Despite tremendous efforts and progress in medical research, cancer remains one of the major causes of human death worldwide.


NPO Research Institute of Fucoidan

Our organization has carried out the following activities based on our "philosophy, beliefs, and missions" aiming to help people live healthy and comfortable lives through diet, by widely disseminating the benefit of "fucoidan" which is a high molecular polysaccharide, extracted from seaweed (brown algae). Fucoidan is said to have a natural healing power (immunity) activation component.

We have conducted a variety of joint research and experiments with Kagoshima University and Kyushu University in our attempt to discover the cancer stopping effects and other efficacy of fucoidan, and have shared the research results and information.

[Kagoshima University] [Kyushu University]
[Our focus in our research] 
・Discovering cancer suppression effects of fucoidan mixed foods : By animal experiments and clinical application 
・Discovering cancer inhibitory effects of fucoidan mixed foods 
・Discovering effects of fucoidan mixed foods in terms of obesity suppression, high blood glucose suppression, anti-tumor effect and natural killer (NK) activity enhancing capacity


Founded in 1988 on a personalized, patient-centered approach to cancer care, Cancer Treatment Centers of America® (CTCA) is dedicated to tailoring a combination of cancer treatments to the needs of each individual patient. From genomic tumor assessments to state-of-the-art technologies and evidence-informed supportive therapies that target cancer-related side effects, comprehensive services are delivered by a team of cancer experts, all under one roof.

Inherent in this integrative approach is a commitment to personalized medicine, tapping breakthroughs in genomic testing, precision cancer treatment and other scientific advances to offer patients as many options as possible. Our oncologists, nurses and other clinicians offer a level of expertise that comes with working exclusively with cancer patients. Cancer treatment is all we do.

Cancer Treatment Centers of America

Supporting Research & Websites 

Memorial Sloan Kettering Cancer Center — the world’s oldest and largest private cancer center — has devoted more than 130 years to exceptional patient care, innovative research, and outstanding educational programs. Today, we are one of 47 National Cancer Institute–designated Comprehensive Cancer Centers, with state-of-the-art science flourishing side by side with clinical studies and treatment.

The close collaboration between our physicians and scientists is one of our unique strengths, enabling us to provide patients with the best care available as we work to discover more-effective strategies to prevent, control, and ultimately cure cancer in the future. Our education programs train future physicians and scientists, and the knowledge and experience they gain at Memorial Sloan Kettering has an impact on cancer treatment and biomedical research around the world.

Memorial Sloan Kettering Cancer Center

August 2016

A draft genome of the brown alga, Cladosiphon okamuranus, S-strain: a platform for future studies of ‘mozuku’ biology 

Cladosiphon okamuranus (Chordariales, Phaeophyceae),5 Okinawa mozuku in Japanese, is one of the important edible seaweeds. In Okinawa, C. okamuranushas been cultivated for more than 35 years by several fishermen’s associations, including those in Onna and Chinen Villages. This cultivation history has established several strains of mozuku that have similar morphology and texture. It was reported in the 36th annual report of the Japanese Cabinet Office that approximately 20 kilotons of mozuku (C. okamuranus and Nemacystus decipiens (‘Itomozuku’)) are produced annually, yielding approximately 4 billion Japanese yen in 2006. In addition, C. okamuranus and N. decipiens are sources of fucoidan,6 a sulfated polysaccharide found in the cell-wall matrix of brown algae that has anti-coagulant, anti-thrombin-like, and tumor-suppressant activities.7 Brown algae also produce alginates.8,9

Oxford Journals

FDA Response to the Fukushima Dai-ichi Nuclear Power Facility Incident
March 2014 Update

To date, FDA has no evidence that radionuclides from the Fukushima incident are present in the U.S. food supply at levels that would pose a public health concern. This is true for both FDA-regulated food products imported from Japan and U.S. domestic food products, including seafood caught off the coast of the United States. Consequently, FDA is not advising consumers to alter their consumption of specific foods imported from Japan or domestically produced foods, including seafood. FDA continues to closely monitor the situation at and around the Fukushima Dai-ichi facility, as it has since the start of the incident and will coordinate with other Federal and state agencies as necessary, standing ready to take action if needed, to ensure the safety of food in the U.S. marketplace.

Japan Inspection Association of Food and Food Industry Enviroment
Governed by the Japanese Government

Report of Examination in regards to the safety concerns and quality of the Kanehide Bio Mozuku Extract Fucoidan after the Fukushima Daiichi Nulear Power Plant Accident.

Click on Image to view full report.
  

 Kanehide Bio Co., Ltd
Quality Control Department

Affects of the Fukushima Daiichi Nuclear Power Plant Accident and Radiation Leakage on the Safety of our Products.

Click on Image to view letter from manufacture.
  

​​Fucoidan USA was the first e-commerce retailer to popularize Kanehide Bio Fucoidan in the USA market through our Ebay platform! ​​​​

Fucoidan-USA.com 

We are your trusted source for the highest quality 100% Okinawa Mozuku Fucoidan Extract and Japanese Superfood Supplements! ​​​​​